Scientific Program - Experimental Therapeutics

Friday, May 19
Sierra Ballroom A/B

Experimental Therapeutics

Poster Display - 7:30 - 6:30
Poster viewing 4:00 - 5:30 (author at poster)
Poster Discussion 5:30 - 6:15 - Sierra Ballroom D (Posters 209 - 214)

209

Bleeke

DNA Vaccines Encoding for GD2 Peptide Mimotopes Induce Anti-Neuroblastoma Immunity

210

Huebener

Mutated Ubiquitin Is Essential for Effective Therapeutic Vaccination with Tyrosine Hydroxylase DNA Minigenes Mediated by Antigen Specific CD8+ T Cells

211

Khan

Proteasome Inhibition Enhances the Antitumor/Antimetastatic Effects of Cytokine Therapy in Murine Neuroblastoma

212

Yamashiro

Resistance of MYCN-Amplified Neuroblastoma Xenografts to VEGF Blockade: Interaction of Notch and VEGF Pathways

213

Keshelava

Inhibition of Histone Deacetylase (HDAC1) by siRNA or Small Molecules Sensitizes Multi-Drug-Resistant Neuroblastoma (NB) Cell Lines to Commonly Used Chemotherapeutic Agents

214

Ponzoni

Combined Therapeutic Effects of Vinblastine and Rapamycin in Neuroblastoma

215

Vitali

Development of New Strategies for p53 Reactivation in Neuroblastoma

216

Barbieri

Inhibition of the p53-MDM2 Interaction Sensitizes Neuroblastoma to Apoptotic Cell Death

217

Van Maerken

Targeted Activation of the TP53 Pathway by the Small-Molecule MDM2 Antagonist Nutlin-3 as a New Therapy Concept for Neuroblastoma

218

Pistoia

Generation of Neuroblastoma-Specific Cytotoxic T Lymphocytes (CTL) Using Dendritic Cells Transfected with Tumor mRNA

219

Tatsuta

Immunotherapy for Neuroblastoma Using Dendritic Cell Stimulated by Sendai Virus Vector

220

Chargui

Cytolytic Effect of Vγ9δ2 T Cells on Autologous Neuroblastoma Cell Lines

221

Jensen

Humanized Antibodies Against the Neural Cell Adhesion Molecule (NCAM) Are Functionally Active Against Neuroblastoma in a SCID Mouse Model

222

Croce

Immunotherapy by IL-21-Engineered Neuro2a Cells in a Syngeneic Murine NB Model Involves CTL and Antibody Responses

223

Hank

The Functional Effects of Anti-Hu14.18 Antibody Activity Found in the Serum of Patients Following Infusion of Immunocytokine (IC) Hu14.18-IL2 for Treatment of Neuroblastoma

224

Carlson

Immunogenicity of Neuroblastoma in the Course of Differentiation

225

Corrias

Human NK Cell Infusions Prolong Survival of Metastatic Human Neuroblastoma-Bearing NOD/scid Mice

226

Sheard

Trail on Activated Natural Killer Cells Contributes to Their Cytotoxicity Against Neuroblastoma Cells Expressing TRAIL-R2

227

De Geer

Cytotoxic T Lymphocytes Induce Caspase-Dependent and -Independent Cell Death in Neuroblastomas in a MHC-Non-Restricted Fashion

228

Bleeke

Optimization Strategies of Mimotopes for GD2 Directed Anti-Neuroblastoma Immunotherapy

229

Jensen

Bi-Specific Antibodies for Therapy of NCAM+ Neuroblastoma Induce Antigen Specific T Cell Expansion

230

Orentas

Discovery of New Immunologic Targets in Neuroblastoma by Vaccination in the Context of Regulatory T Cell Depletion: Immunodominance of the DEK Oncogene

231

Tong

Induction of Caspase 8 by 5-Azacytidine Renders NB Cells Sensitive to TRAIL

232

Zhang

The Effect of IFNγ on TRAIL-Induced Apoptosis in Neuroblastoma Cells

233

Segerstrom

The Anti-VEGF Antibody Bevacizumab Reduces the Growth Rate of High-Risk Neuroblastoma Xenografts

234

Pastorino

Combined Tumor- and Vascular-Targeting Enhances the Therapeutic Effects of Liposomal Chemotherapy Against Neuroblastoma

235

Kaneko

Relationship between Growth Inhibition of Neuroblastoma Xenograft and Expression of Hypoxia-Inducible Factor-1α/Vascular Endothelial Growth Factor by Prolonged Low-Dose CPT-11 Administration

236

Varesio

Transcriptional Response of Neuroblastoma to Hypoxia or to the Hypoxia Related Stimulus Picolinic Acid and Its Reversal by Topotecan

237

Segerstrom

Sensitivity of Endothelial Cell towards Commonly Used Chemotherapeutic Agents

238

Johnsen

A Novel Celecoxib Derivate, OSU03012, Induces Caspase-Dependent Cytotoxicity and Cell Cycle Arrest in Neuroblastoma

239

Rasmuson

Neuroblastoma Cells Express All Four Prostaglandin E2 (PGE2) Receptor Subtypes and Specific PGE2-Receptor Antagonists Inhibit Tumor Growth

240

Keshelava

Formalized Pre-Clinical Drug Testing To Facilitate Clinical Trial Development in the New Approaches to Neuroblastoma Therapy (NANT) Consortium

241

Harned

Sodium Thiosulfate (STS) Administered Six Hours after Cisplatin Does Not Compromise Anti-Neuroblastoma Activity

242

Goldsmith

Novel Pro-Death BH3 Peptidomimetics Re-Engage Apoptosis and Reverse Chemoresistance in Neuroblastoma

243

Goldsmith

Synthetic Small Molecule Bak-Domain Mimics Potently Induce Apoptosis in NB Cell Lines

244

Raschella

Activity of IGF1R Inhibitor NVP-AEW541 on Neuroblastoma Proliferation, Apoptosis and Invasion

245

Kim

In Multi-Drug Resistant Neuroblastoma Cell Lines, Sphingosine Kinase 1 mRNA Is Over-Expressed and Induced by Drugs Whose Resistance Is Modulated by Sphingosine Kinase Inhibitors

246

Segerstrom

Phosphorylated Akt and mTOR Is Abundantly Expressed in Neuroblastoma Tumours and Rapamycin and Its Analogue CCI-779 Show Promising Anti-Tumour Effects in Human Neuroblastoma

247

Saulnier Sholler

Isothiocynates and Derivatives Such as Sulforophane Induce Caspase Mediated Apoptosis in Neuroblastoma and Suppress AKT and ERK1/2 Signaling

248

Armstrong

Effects of BZ-423 on Cell Viability and N-myc Protein Stability in Neuroblastoma

249

Armstrong

Bortezomib as a Therapeutic Candidate for Neuroblastoma

250

Valerie

Toxicity of Velcade on Neuroblastoma Cell Lines

251

Gleissman

Omega-3 Docosahexaenoic Acid Is Toxic to Neuroblastoma In Vitro and In Vivo

252

Hadjidaniel

Antagonism of Etoposide Cytotoxicity for Neuroblastoma by Retinoic Acid Is Mediated by the Anti-Apoptotic bcl-2 Family Proteins

253

Niizuma

Bcl-2 Is a Key Regulator for the Retinoic Acid-Induced Apoptotisis of Neuroblastoma

254

Armstrong

Effect of R116010 on Retinoic Acid Metabolism and Efficacy in Neuroblastoma

255

Ikegaki

Retinoid-Resistance and Favorable Neuroblastoma Genes

256

Redfern

Over-Expression of RARγ Increases Death of SH-SY5Y Neuroblastoma Cells in Response to Retinoic Acid but Not to Fenretinide

257

Liu

Subcutaneous Tumor Exposure to Fenretinide in Neuroblastoma Murine Xenografts Is below Most Tissues and Potentially Limits Tumor Responses

258

Imrie

Bortezomib and Fenretinide-Induced Apoptosis: A Novel Approach to Adjuvent Therapy of Neuroblastoma?

259

Lovat

Fenretinide-Induced Apoptosis through Targeted Endoplasmic Reticulum Stress: Definition of Novel Targets for Neuroblastoma Therapy

260

Lovat

The NF-kB Pathway Mediates Fenretinide-Induced Apoptosis in SH-SY5Y Neuroblastoma Cells

261

Armstrong

p53-Independent Induction of NOXA in Response to Fenretinide [ndash] A Novel Therapeutic Strategy for Neuroblastoma?

262

Kraveka

Dihydroceramide Desaturase Enzyme as a Target for Neuroblastoma Therapy

263

Ferrante

Novel Cationic Ceramides as Chemotherapeutic Agents in Human Neuroblastoma Cells

264

Wagner

O6-Benzylguanine Pretreatment Sensitizes Neuroblastoma Cells to Temozolomide and Irinotecan Regardless of the Level of MGMT Expression

265

Tamura

Gefitinib Induces Apoptotic Cell Death in Neuroblastoma Cells

266

Tabata

Proteomic Analysis of Apoptosis Mechanism Induced by Xanthoangelol, a Major Chalcone Constituent of Angelica keiskei, in Neuroblastoma

267

Gross

Histone Deacetylase Inhibitors Strongly Sensitise Neuroblastoma Cells to TRAIL Induced Apoptosis by Caspases Dependent Increase of Pro- to Anti-Apoptotic Proteins Ratio

268

Subramanian

CREB-Binding Protein (CBP) Mediates Apoptotic Effects of Histone Deacetylase Inhibitors on Neuroblastoma (NB) Cells

269

Wickstrom

Activity of the Alkylating Dipeptide J1 in Neuroblastoma Cell Lines In Vitro and In Vivo

270

Lokke

The Antimicrobial Peptide LfcinB Is Cytotoxic to Neuroblastoma Cell Lines In Vitro and In Vivo

271

Saulnier Sholler

Combination Treatment of Nifurtimox with Buthionine Sulfoximine or Ascorbic Acid Enhances the Cytotoxicity to Neuroblastoma

272

Bachmann

Syringolin A, a New Plant Elicitor from the Phytopathogenic Bacterium Pseudomonas syringae pv. syringae, Induces Apoptosis in Human Neuroblastoma Cells

273

Bagatell

Effects of the Heat Shock Protein 90 Inhibitor 17-Dimethylaminoethylamino-17-Demethoxygeldanamycin (17-DMAG) in Neuroblastoma Cells

274

Jayanthan

Studies on the Effectiveness and Biological Correlative Analysis of 17-DMAG on Neuroblastoma (NB) Cells

275

Mairs

Radiation Induced Biological Bystander Effect Elicited In Vitro by MIBG Labelled with Alpha-, Beta- and Auger Electron Emitting Radionuclides

276

McCluskey

[131I]Meta-Iodobenzylguanidine Targeted Radiotherapy: Utilising Tumour Specific and Radiation-Inducible Promoter Elements To Control NAT Gene Expression

277

Yeung

Arsenic Trioxide Can Induce G2/M Phase Cell Cycle Arrest in Selected Neuroblastoma Cell Lines

278

Wang

Neuronal Differentiation and TrkA Expression of Neuroblastoma Induced by the Combination Treatment of Interferon gamma and NGF

279

Li

Studies of Anti-Proliferation and Apoptosis after Combined Treatment of IFN-γ and Doxorubicin in Caspase-8 Silenced Neuroblastoma Cell Line

280

Montaldo

Antitumour Activity of Sodium Ascorbate Against Neuroblastoma Cell Lines In Vitro

281

Bachmann

Polyamine Depletion Induces p27Kip1, Downregulates MYCN, and Leads to Retinoblastoma Protein Rb-Mediated G1 Cell Cycle Arrest in MYCN-Amplified Human Neuroblastoma Cells

282

Nara

Silencing MYCN by RNA Interference Induces Growth Inhibition, Apoptotic Activity and Cell Differentiation in a Neuroblastoma Cell Line with MYCN Amplification

283

Feng

Targeted Delivery of MYCN siRNA Formulated in Folate Receptor-Targeted Lipid Vesicles into LA-N-5 Cells

283a

Garcia

Comprehensive Profiling of the Cell Surface Proteome in Neuroblastoma Using Quantitative High Resolution Mass Spectrometry



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