Scientific Program - Molecular and Cell Biology

Thursday, May 18
Sierra Ballroom A/B

Molecular and Cell Biology

Poster Display - 7:30 - 6:30
Poster viewing 4:00 - 5:30 (author at poster)
Poster Discussion 5:30 - 6:15 - Sierra Ballroom D (Posters 34-40)

34

Takita

Genome-Wide Copy Number Analysis of Neuroblastoma Using Ultra High-Density SNP-Genotyping Microarrays

35

Mosse

A Customized Neuroblastoma BAC-Based Array Comparative Genomic Hybridization (aCGH) Platform Identifies a Narrow Region on Chromosome 3p as Frequently Deleted during Tumor Progression

36

Spitz

Oligonucleotide Array-Based Comparative Genomic Hybridization (aCGH) of 90 Neuroblastoma Cases Reveals a Close Association between Aberration Pattern, Clinical Phenotype and Outcome

37

Perri

Novel Chromosomal Regions for Genetic Predisposition to Familial Neuroblastoma

38

Hogarty

A Model of MycN-Initiated Neural Cell Oncogenesis Shows a Surprising Predilection for Complete Suppression of MycN during Progression

39

Igarashi

Transcriptional Silencing of CHD5 Expression by Methylation in Human Neuroblastomas

40

Flahaut

Amplification and Overexpression of the Wnt1 Receptor Frizzled-1 Gene in Multi-Drug Resistant Neuroblastoma Cells, Mediates Sustained Activation of the Wnt/beta-Catenin Pathway

41

Olsson

Analyses of 160 miRNA Species in Neuroblastoma Tumor Samples Reveal Stage Specific miRNA Fingerprint

42

Westermann

Cloning and Characterization of miRNA Transcripts from Clinically Divergent Neuroblastoma Subtypes

43

Zollo

New mi-R Genes in Neuroblastoma

44

Henriksen

Inducible shRNA Expression in Neuroblastoma Cell Lines

45

Pattyn

Distinguishing Direct and Secondary MYCN Downstream Targets by Combined Expression Profiling and Gene Promoter Analysis

46

Perini

Direct and Concerted Regulation of Multidrug Resistance Genes by the N-Myc Transcription Factor in Neuroblastoma

47

Ichikawa

Suppression of Neuronal Differentiation in Unfavorable Neuroblastoma and Its Association with MYCN Amplification

48

Ikegaki

De Novo Identification of MIZ-1 (ZBTB17) Encoding a MYC-Interacting Zinc-Finger Protein as a New Favorable Neuroblastoma Gene

49

Douc-Rasy

TAp73 and MYCN Expression Levels Are Inversely Correlated in p53-Deficient Neuroblastoma Cells

50

Rawwas

MycN Regulation of Cellular Retinoic Acid Binding Protein-II in Neuroblastoma

51

Stock

Gene Clusters Proximal to the MYCN Locus Are Highly Expressed in Human Neuroblastoma Cell Lines

52

Weber

The Structure of the MYCN Amplicon Is an Invariable Attribute in Human Neuroblastoma

53

Pattyn

Disentangling MYCN Downstream Gene Cascades Via Meta-Analysis of Known Targets Stored in the MYCNot Database

54

Fix

Characterization and Role of Amplicons in the Development of Neuroblastoma

55

Michels

Rare Amplicons in Neuroblastoma Harbour Neuronal Developmental Genes with a Putative Role in Neuroblastoma Oncogenesis

56

Horn

Generation and Characterisation of an Inducible N-MYC-ER System in Neuroblastoma Cells

57

Ash

MYCN-Gain Compared to MYCN Amplified Neuroblastoma: Biological and Clinical Characteristics

58

Castel

Immunohistochemical Expression of mycN Protein in Neuroblastoma: A Comparison with MYCN Gene Status

59

Wechsler

Mxi1 and Mxi1-0 Antagonize MycN-Dependent Proliferation and Apoptosis in SHEP Neuroblastoma Cells

60

Bilke

High Resolution CGH of Advanced Stage Neuroblastoma

61

Schleiermacher

Array-CGH Analysis of 29 Stage 4S Neuroblastoma Samples Reveals a Poorer Outcome in Case of Segmental Chromosome Changes

62

Schleiermacher

Chromosomal CGH in Neuroblastoma without MYCN Amplification Identifies Patients with a Higher Risk of Relapse

63

Guillaud-Bataille

Array-CGH Dissection of 17q Abnormalities in Neuroblastoma Genome Suggests at Least Three Distinct Regions of Interest

64

Van Roy

Multi-Color Interphase FISH Study of Intratumoral Heterogeneity of Chromosome 17(q) Status in Neuroblastoma Tumors

65

Vandepoele

A Constitutional Translocation t(1;17)(p36.2;q11.2) in a Neuroblastoma Patient Disrupts NBPF1, a Member of a Recently Expanded Gene Family

66

Laureys

Search for Genes Predisposing to Neuroblastoma

67

Asgharzadeh

Identification of Loss of Heterozygosity Regions in MYCN Non-Amplified Metastatic Neuroblastomas by Comparing Whole Genome Amplified Normal Mononuclear Cells and Micro-Dissected Tumor Tissue

68

Scaruffi

High Resolution Oligonucleotide Array-Based Comparative Genomic Hybridization Identifies Genome Imbalances In Primary Neuroblastoma Tumors

69

Carr

Comparison of Single-Nucleotide Polymorphism Arrays, Comparative Genomic Hybridisation and Conventional Karyotyping To Detect Allelic Imbalance in Neuroblastoma Cell Lines

70

George

Analysis of Neuroblastoma Tumors and Derivative Cell Lines Using Single Nucleotide Polymorphism Arrays

71

Moreno

Short Tandem Repeat Genotyping Using Identifiler Is a Reproducible and Cost-Effective Method for Establishing and Monitoring Identity of Neuroblastoma Cell Lines

72

Diskin

Complex Patterns of Genomic Alterations Correlating with Disease Progression in Neuroblastoma Are Revealed Using a New Statistical Analysis Method

73

Fischer

Molecular Features of Neuronal Differentiation Define Subtypes of Neuroblastoma with Favorable and Unfavorable Outcome

74

Eils

Integration of Different Neuroblastoma Data Types into iCHIP, a Flexible Data System for High-Throughput Data

75

Brors

Construction and Validation of a Neuroblastoma-Specific Custom Microarray

76

Song

Parallel Isotope-Coded Affinity Tag (ICAT) Analysis and mRNA Expression Profiling of Neuroblastoma; a Pilot Study

77

Chen

Cross Platform Comparison using cDNA and Affymetrix Microarrays for Predicting Prognosis in Patients with Neuroblastoma

78

Schramm

Combining Transcriptome and Proteome Analysis for Deciphering the Effects of Neutrotrophin Receptor Expression and Activation in Neuroblastoma Cells: A “Best of Both Worlds” Approach

79

Tonini

Gene Expression Profiling of Neuroblastoma and Ganglioneuroblastoma Reveals Differences between Neuroblastic and Schwannian Stromal Cells

80

Jarzembowski

Intratumoral Gene and Protein Expression Differences between the Neuroblastic and Stromal Components Predict Malignant Potential

81

Hiyama

Genome-Wide Microarray Analaysis for Risk Assessment of Neuroblastoma Patients

82

Jackson

Cancer Outlier Profile Analysis of Microarray Data Identifies Neuronal Genes Whose Expression Correlates with Stage and Survival in Neuroblastoma

83

Mora

Identification of Candidate Tumor Related Genes Using Comprehensive Gene Expression Analysis of Neuroblastic Tumors

84

Tajiri

The Biological Classification of Neuroblastoma Using a Novel Prognostic Factor Based on a Microarray System

85

Vandesompele

Neuroblastoma Microarray Gene Lists: Powerful Tools for Data Mining and Identification of Critical Genes

86

Stallings

High Resolution Analysis of Chromosomal Breakpoints and Genomic Instability Identifies PTPRD as a Candidate Tumor Suppressor Gene in Neuroblastoma

87

Ejeskar

In Vitro-Transcribed mRNA from Five Genes from the 1p36.2-Region Have Tumor Suppressor Properties When Transfected into Neuroblastoma Cells

88

Fransson

Significant Decrease in mRNA Expression of Five Genes Mapped at 1p36.2, Comparing Favorable and Unfavorable Neuroblastomas

89

Geli

Anti-Tumorigenic Effects of RASSF5 in Human Neuroblastoma

90

Liu

Molecular Cloning and Characterization of Human Castor (CASZ1), a Novel Human Gene Upregulated during Cell Differentiation

91

Raabe

PHOX2B Suppresses Neuroblastoma Tumorigenesis by Promoting Cellular Differentiation

92

Versteeg

Microarray Studies of PHOX2B and MYCN Pathway Genes Mark Differences in Tumor Types

93

Perri

Over-Expression of PHOX2A and PHOX2B in Human Neuroblastoma

94

Krona

Classical Tumor Suppressor Inheritance Pattern of PHOX2B in a Patient with Multifocal Stage 4M Neuroblastoma

95

Grau

Methylation Analysis of RASSF1A, BLU, EMP3, CFTR, RIZ1, NDN and hMLH1 Genes in Neuroblastoma

96

Yang

Epigenetic Changes of DCR2, CASP8, and HIN-1 in Neuroblastoma Tumors Are Associated with Poor Outcome

97

Fagin

Identification of Aberrantly Methylated Genes Involved in Therapy Resistance of Neuroblastoma

98

Ramani

Expression of Retinoic Acid Receptor beta 2 Is Linked to Methylation of Retinoic Acid Receptor Beta 2 Promoter

99

Nakamura

A Novel Loss-of-Function Mutation of p53 Caused by Homozygous Deletion in SK-N-AS Neuroblastoma Cells Highly Resistant to Anti-Cancer Drugs

100

Li

NEDL1 (NEDD4-Like Ubiquitin Protein Ligase-1) and NEDL2 Are Novel Prognostic Indicators Highly Expressed in Favorable Neuroblastomas and Mediates the p53- and p73-Dependent Apoptosis, Respectively

101

Kurata

Stress Via HDM2/p53 Pathway Causes Apoptotic Cell Death by Mitochondrial Noxa Up-Regulation in Neuroblastoma Cells

102

Armstrong

Serial Signaling through p53, H-Ras, MEK, and NF-κB Determines Chemotherapy Responsiveness of Neuroblastoma

103

Li

Effects of TrkB and BDNF Level on Chemoresistance in Neuroblastoma

104

Li

Phosphorylation and Inactivation of Glycogen Synthase Kinase-3ß by BDNF/TrkB Protects Neuroblastoma Cells from Chemotherapy-Induced Cell Death

105

Ishola

Phosphatidylinositol 3-Kinase Regulation of Gastrin-Releasing Peptide-Induced Cell Cycle Progression in Neuroblastoma Cells

106

Lipska

Mutational Analysis of NTRK Gene Family in Primary Neuroblastoma Tumours

107

Shimada

Expression Profile of Receptor Tyrosine Kinases Correlates to the Prognosis of Neuroblastoma

108

Minturn

P75 Neurotrophin Receptor Expression and Signaling in Neuroblastoma

109

Ho

The Effect of P75 on Trk Receptors in Neuroblastoma

110

Kawasaki

The Secretory Proteins, Neurexophilin-1 and Neurexophilin-2, Are Differentially Expressed in Both Tumor Tissues and Blood of the Patients with Favorable and Unfavorable Neuroblastoma and Predict the Prognosis

111

Astrahantseff

Serum Profiling of Neuroblastoma Patients Using SELDI Mass Spectometry

112

Sandoval

Analysis of Neuroblastoma Progression: Proteomic-Based Identification of Tumor-Associated Serum Biomarkers

113

Master

Proteomic Profiling of Genetically Diverse Neuroblastoma Cell Lines

114

Davis

Analysis of the Secretory Proteome of High-Risk Neuroblastoma To Identify Potential Serum Biomarkers for Risk Assessment

115

Ikeda

Identification of Differentially Expressed Proteins of a Neuroblastoma Cell after Low Serum Stimulation by 2D-DIGE

116

Fluchel

Pro-Survival Mcl1 Is the Predominant Bcl2 Homologue in Neuroblastomas and a Rational Therapeutic Target

117

Sakai

Analysis of Biological Function of ShcC Docking Protein in Neuroblastoma

118

Voth

Identification and Characterization of DEIN, a Novel Gene Differentially Expressed in Primary Neuroblastoma

119

Vasudevan

MKP8: A Novel Molecular Target in Neuroblastoma

120

Bourdeaut

Schwann-Cells and Neuroblasts May Share the Same Monoclonal Pattern of X Inactivation in a Subset of Stroma-Rich Neuroblastic Tumours

121

Budhram-Mahadeo

The Brn-3b Transcription Factor Is Elevated in Many High Stage Neuroblastoma Tumours and Activate Genes Associated with Development and Progression of Neuroblastomas

122

Ge

A Novel Homeobox-Containing Transcription Factor Is Involved in Regulating Neuroblastoma Cellular Proliferation

123

Hiyama

Telomere 3' Single-Strand Overhang Length in Neuroblastoma

124

Muth

Progression Versus Regression in Neuroblastoma: Identify and Characterize New Players Targeting the Retinoblastoma-Pathway

125

Gallego

Characterization of New Splicing Variants Occurring in the C-Terminal Domain of Human Tyrosine Hydroxylase in Neuroblastic Tumors



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